serum amyloid

serum amyloid
In secondary amyloidosis the fibrils deposited in tissues are unrelated to immunoglobulin light chains (in contrast to the situation in primary amyloidosis) and are made of amyloid A protein (AA protein). This is derived from serum amyloid A (SAA) that is the apolipoprotein of a high-density lipoprotein and an acute phase protein. Partial proteolysis converts SAA into the beta pleated sheet configuration of the amyloid fibrils. Amyloid P protein is also found as a minor component of the fibrils (in both primary and secondary amyloidosis) and is derived from serum amyloid P that has similarity to C-reactive protein. The physiological role remains obscure.

Dictionary of molecular biology. 2004.

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  • Serum amyloid A — protein Name = Human Serum amyloid A1 caption = width = HGNCid = 10513 Symbol = SAA1 AltSymbols = EntrezGene = 6288 OMIM = 104750 RefSeq = NM 199161 UniProt = P02735 PDB = ECnumber = Chromosome = 11 Arm = p Band = 15.1 LocusSupplementaryData =… …   Wikipedia

  • Serum amyloid P component — Amyloid P component, serum (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called amyloid .cite journal | author = Cathcart… …   Wikipedia

  • serum amyloid P-component — Precursor of amyloid component P, found in basement membrane. Member of the pentraxin family. See serum amyloid …   Dictionary of molecular biology

  • serum amyloid A protein — a high molecular weight protein synthesized in the liver; it is an acute phase protein and circulates in association with a subclass of HDL lipoproteins. It is the precursor to AA amyloid and accumulates in inflammation. Called also SAA p …   Medical dictionary

  • Amyloid — Amyloids are insoluble fibrous protein aggregates sharing specific structural traits. Abnormal accumulation of amyloid in organs may lead to amyloidosis, and may play a role in various other neurodegenerative diseases. Definition controversyThe… …   Wikipedia

  • amyloid — Glycoprotein deposited extracellularly in tissues in amyloidosis. The glycoprotein may either derive from light chain of immunoglobulin (AIO (amyloid of immune origin): 5 18 kD glycoprotein; product of a single clone of plasma cells, the N… …   Dictionary of molecular biology

  • amyloid A — AA amyloid a pathological fibrillar low molecular weight protein formed by cleavage of serum amyloid A (SAA) protein. It is deposited in the tissues secondary to chronic inflammatory conditions; see AA amyloidosis, under amyloidosis …   Medical dictionary

  • SAA protein — serum amyloid A p …   Medical dictionary

  • SAA2 — Serum amyloid A2, also known as SAA2, is a human gene. [cite web | title = Entrez Gene: SAA2 Serum amyloid A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6289| accessdate = ] PBB Summary section title …   Wikipedia

  • SAA1 — Serum amyloid A1, also known as SAA1, is a human gene.cite web | title = Entrez Gene: SAA1 serum amyloid A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6288| accessdate = ] PBB Summary section title =… …   Wikipedia

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